KMID : 1031120150050010009
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Journal of Epilepsy Research 2015 Volume.5 No. 1 p.9 ~ p.12
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Parents¡¯ Subjective Assessment of Effects of Antiepileptic Drug Discontinuation
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Kim Gun-Ha
Byeon Jung-Hye Eun So-Hee Eun Baik-Lin
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Abstract
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Background and Purpose: Many parents express worries about potential negative side effects of antiepileptic drugs (AED) on cognition, behavior, mood, and academic achievement. We aimed to evaluate parents¡¯ subjective feelings about cognitive or behavioral changes in their children and their quality of life after antiepileptic drug (AED) discontinuation.
Methods: A modified questionnaire based on the Korean-Quality of Life in Childhood Epilepsy and the Korean-Child Behavior Checklist was answered by parents whose children were seizure-free over the course of 1 month after AED discontinuation. All children were seizure-free for at least 2 years before AED withdrawal.
Results: Fifty-eight eligible patients (mean age, 14.1 ¡¾ 4.5 years) were examined. Except valproate in cognition (p = 0.03), parents did not feel significant change after discontinuation of different drugs. They felt improvement of behavior in generalized epilepsy (p = 0.04) and better quality of life in children less than 6 year of age at diagnosis of epilepsy (p = 0.02).
Conclusions: We propose that factors such as earlier age at diagnosis of epilepsy or type of epilepsy might influence parents¡¯ subjective feelings about their children¡¯s well-being after drug discontinuation, rather than the drug itself.
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KEYWORD
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Anticonvulsants, Epilepsy, Quality of life, Cognition
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